Patients with Parkinson’s Disease Get Better After Receiving Stem Cell Treatment

Recently, the United States Health Day News reported news with the title Parkinson’s Patient Improving After First-Ever Stem Cell Therapy. For the first time, scientists have transformed Parkinson’s patients’ own skin cells into key brain cells, and have achieved considerable results.

Scientists used the patient’s own skin cells to generate induced pluripotent stem cells (iPSC) in vitro, and then they differentiated the iPSCs into midbrain dopaminergic precursor cells. After testing, patient-specific dopaminergic precursor cells have the phenotypic characteristics of substantia nigra neurons, and experiments with humanized mouse models have shown that these cells lack immunogenicity.

Subsequently, these cells were implanted into the Parkinson’s patient for two times at intervals of 6 months. The transplantation sites were the left and right hemisphere putamen, and the patient did not receive immunosuppressive treatment during this period. The positron emission tomography showed that the cells survived steadily in the patient. After 18-24 months of transplantation treatment, this patient’s Parkinson’s clinical symptoms tended to be stabilized or even improved.

“It has been two years since the stem cell transplantation treatment began, and the patient has not experienced serious side effects. Parkinson’s clinical symptoms have been stabilized or even improved.” The patient’s attending doctor also said that the improvement is moderate, but before receiving stem cell transplantation, his condition deteriorated quickly, and this kind of condition had stopped after the treatment. This case gave Parkinson’s patients great encouragement, proving the feasibility and safety of this stem cell transplantation treatment.

However, this treatment still takes a long time to maker a further exploration before it is widely promoted. First of all, it is difficult to popularize this therapy on a large scale since inducing the induction of pluripotent stem cells, and differentiating into dopaminergic progenitor cells require very high production routes. Secondly, how to benefit patients by transplantation? To solve this problem, it still needs many more practice. In the case, the 69-year-old patient reported that his life improved rapidly shortly after the operation. It does not rule out the possibility of other effects, and the mechanism of how stem cells improve the life of Parkinson’s patients in a short period of time still requires further exploration.

Parkinson’s incidence is the second, which is only lower than Alzheimer’s disease. Acording to statistics, it is the second largest neurodegenerative disease, with an incidence of more than 2% in people over 65 years of age. Now, there are more than 10 million Parkinson’s patients worldwide. However, at present, Parkinson’s treatment is mainly to relieve symptoms, there is no cure, and cell transplantation is the most promising treatment for this disease. The principle is to increase the level of dopamine by transplanting cells into the striatum or midbrain substantia nigra of Parkinson’s patients to achieve the purpose of improving exercise.

In addition to the induced pluripotent stem cells in the above case, the most widely used treatment in clinical studies are mesenchymal stem cells. Mesenchymal stem cells have the advantages of convenient material extraction, easy separation and culture, as well as autoimmunity without immunogenicity.

Stem cell transplantation is proved to have the potential to treat Parkinson’s disease, and this case shows that iPSCs transplantation treatment is both feasible and safe, and can even block the progression of the disease and improve clinical conditions. This novel research report undoubtedly brought hope to the majority of patients with Parkinson’s disease.

In recent years, more and more studies have confirmed that stem cell therapy, including induced pluripotent stem cells and mesenchymal stem cells, has clinical application prospects, which shows that the prospect of stem cell therapy for Parkinson’s disease is also very promising.

How B2B eCommerce Digital Solutions Benefit Manufacturers?

Rise in global retail eCommerce and the successful B2C model has led B2B large enterprises and SMBs to replicate it on the B2B eCommerce digital platforms. The aim is to primarily bring the superior tech-driven shopping experience of retail eCommerce to B2B eCommerce and using collaborative software to interface with customers. By 2030, it’s expected that 90 percent of global manufacturing organizations will use B2B eCommerce digital solutions. This will aid them to connect with customers to satisfy demand, execute supply needs, for offering product services and initiate R&D-based product development.

Growth of B2B eCommerce Digital Solutions

With B2B eCommerce showing the potential like its retail counterpart, there are industries like telecom, travel, computers, electronics, apparel, industrial, aerospace, automobile, health science, life sciences and pharmaceuticals, banking and finance, education and others that are understanding how digital eCommerce can bring the ROI for their business.

A rethink on the traditional sales approach has opened new online channels for business growth. Besides this, Marketing and Sales teams are now considering an omnichannel approach for a B2B prospect when nurturing them in these multiple channels.

Get in Touch for Best eCommerce Digital Solution – https://katalysttech.com/get-in-touch

B2B manufacturing organizations are now exploring the full potential of eCommerce platforms like Magento, Shopify by integrating their Marketing, Sales and Finance processes to offer a cohesive experience to their customers across various touchpoints. Moving from their legacy systems to SaaS-based on-demand platforms brings scalability to their business. For this, they can enlist the services of tech partners like Katalyst Technologies and ensure ongoing support for driving upgrades and adding new features.

Why B2B eCommerce Digital Solutions are Needed for Manufacturers

Surveys have shown that B2B eCommerce has led to cost savings for manufacturers in customer acquisition, besides leading to speedier sales closures, better collaborations with partners and customers. The ease of adding new prospects to the sales funnel can motivate most manufacturers to use these platforms by the turn of the decade.

What Deters Manufacturers from Leveraging B2B Ecommerce

Often, manufacturers who have just started with B2B eCommerce digital activities, think it’s enough merely to present their offerings on the platform. On the contrary, the model needs some serious strategy-building with the focus on how the manufacturer’s online presence can align with business goals. For this, just like B2C businesses, you need to ensure your product catalogs are always updated, your online platform is device-agnostic and showcases your products appropriately on any device. In addition to this, it’s important to make it easy for your customers to transact on the platform using multiple methods.

The security of data on a digital platform for organizations and their customers is a decisive factor in adopting a B2B eCommerce platform. Cost implications of extending the existing technology infrastructure too can act as a deterrent. However, more than these factors it’s the mindset of the decision-makers to continue with what’s working well and not being open to change that hampers investing in a B2B eCommerce platform.

Important Considerations for Manufacturers to Adopt B2B Ecommerce

To implement B2B eCommerce digital network in an efficient manner, firstly, manufacturers must ensure only clean data is migrated to the platform. This will help with extracting accurate analytics for customer activity and work on the gaps in conversions based on data. Not just external data, internal data also need to be aligned precisely and tagged well to make the right decisions that drive business goals. For instance, a simple exercise like aligning the back end and front end to showcase your product features optimally is a data activity that needs proper execution.

Secondly, manufacturers must check the upgrades needed to their technology framework to integrate B2B eCommerce digital solutions for their business. Besides technology requirements, manufacturers may also have to add resources for eCommerce tasks, ensure data governance and compliance with GDPR, CCPA or any other consumer protection guidelines, and establish a data-driven analytics outlook. A proper eCommerce implementation and integration partner like Katalyst Technologies oversees such requirements of:

Extending tech frameworks,
Driving integrations based on the complexities of the eCommerce platform,
Transitioning from an older approach to newer ones with minimal effect on customers or business
Hand-holding the manufacturer through the transformation be it for data management, interfacing with their internal and external stakeholders like Marketing or Sales teams and software vendors for cloud respectively.
Features of B2B eCommerce Digital Solutions

Much like retail eCommerce, B2B eCommerce digital solutions too, aim to bring multi-device convenience to their clients, besides aftersales services and providing opportunities for lead generation on their platforms.

To ensure interactions remain on the B2B eCommerce platform itself and not on email or other traditional ways, buyers and sellers have the option of transacting goods and services over social channels and mobile platforms. This also brings faster closure of sales deals and enhances manufacturer branding while enriching customer engagement.

Every manufacturer aims to extend their business reach beyond their countries and virtual stores, giving their B2B customer the feel of a physical store using ecommerce digital solutions. Some of the tech successes seen in B2B ecommerce for manufacturers has been in:

Integrating e-procurement options,
Bringing order requisitions and its entries onto the platform so that sales, customers and suppliers are seeing the same dashboard,
Offering visibility to dealers through online contract management using real-time data,
Expenses management dashboards,
ERP integrations for shipping, taxation, ideal pricing,
Building quote-to-order capabilities in the ordering system, and
Providing a subscription business model.
Katalyst Technologies brings a consolidated view to the manufacturer of the technology needed to fulfill their business goals and how these are achieved with integrated B2B eCommerce digital solutions.

Upcoming Trends in B2B eCommerce Digital Solutions

With the phenomenal growth of the B2C online marketplaces, the extensive R&D has also led to some trends being borrowed in B2B eCommerce digital solutions. Here are some that are a must-have:

A 24/7 global marketplace and a multi-device, multi-location accessibility has driven platforms to incorporate Amazon-like capabilities that allow for personalization, cross-selling, upselling, triggering discounts and offers and similar features. Also, multichannel visibility of customer journeys is now a common feature of all B2B eCommerce platforms. Customers can log in through a social platform and end up buying from manufacturers at an offline event and their requirements get recorded on the eCommerce platforms from the first touchpoint to the actual sale. Besides this, punchout catalogs and e-procurement systems with automatic and customized options is also provided on the platform.
B2B eCommerce digital solutions have also adopted Product Information Management (PIM) systems like their retail counterparts, where both internal and external are aligned accurately. This includes information about the manufacturing systems, ERP data, data from platforms that aggregate content, data from Global Data Synchronization Network (GDSN), and supplier and vendor data, product-related data be it videos, texts and visuals, and other copyrighted material. Once all the data is collated, PIMs also ensure this reaches every customer touchpoint in their preferred manner, be it on the web, at an event session, on the mobile or any other choice made, thereby helping manufacturers to open up every window of opportunity to expand their business.
There are several tools, especially for managing content and related activities, that are helping manufacturers by finding the right target audience and creating better customer engagement. One such useful tool for B2B eCommerce digital solutions is a robust Content Management System (CMS) with an experience management software built into it to provide a great user experience. In addition to this, the CMS can direct well-aligned content to the customers as per their roles in the B2B ecosystem.
Future B2B eCommerce digital solutions will also provide a self-serve structure, so manufacturers can always engage with their customers without depending on their IT teams to resolve issues that hamper this. Going forward, industry customized solution frameworks and tech-paced developments will figure into the B2B platform as they take place.
How Manufacturers Can Implement B2B eCommerce Digital Solutions

It’s ideal if the manufacturing industry works with a technology implementation partner, whose focus is to create as many channels for online sales as is possible and has considerable experience in the eCommerce domain. Manufacturers must assess their tech partners to understand how they are bringing together people, processes, and technologies for your set-up to have a competitive edge over others. Offering expertise in deciding on the right B2B eCommerce platform and creating IT interfaces that improve the quality of business offerings through actionable intelligence is also the responsibility of your tech partner.

Your solutions provider must also ensure they provide an omnichannel integration and help you understand how the platform interfaces with mobile and social. Also, essential is to know how to use these as sales channels by reworking the Marketing and Sales processes to align with the B2B eCommerce digital solutions implemented, while continuing to work on optimizing the existing channels.

As a manufacturer, you must assess if your tech partner has done research on your specific industry and your B2B eCommerce requirements in terms of direct selling, sell-through or any other. The platform integration discussions that follow are to be based on this research to accelerate the achievement of your business goals. So, for instance, the solution must have cataloging that reflects the industry’s views and UX inputs, as only then will the output appear new and improved.

Katalyst Technologies is a certified Magento and Shopify partner and worked with various manufacturing sectors to bring a positive change in their KPIs through guided best tech practices and processes that drive operational efficiencies at a reduced cost, and improved customer loyalty and sales. So, connect with our experts now, no matter what phase of your B2B eCommerce digital journey you are at and let us help you bring your customers closer. Katalyst’s rich experience in implementing multiple eCommerce platforms is a key differentiator and makes us focus on the most critical factors of your business including automation for ease, customer experience, and standardized yet customized integrations.

How to Invest Your Hard Earned Money

Nowadays, there is an increasing craze among the people regarding Investment. This is a very good thing for the country and for the people of the country, but while investing, most people do not know how to invest their hard-earned money. Investing is an Art. Anyone who knows this art reaches from the floor to the top in the investment world. They are able to fulfill all their life’s dreams.

Where to invest money? This question is very important, but how to invest money? It is more important than that. For example, if you ask people where do I invest my money? So many people will tell you to invest in the stock market. Then some will say- no. not! Do not invest in the stock market! Is very Risky. You invest in mutual funds. But if you ask how to invest in Mutual Fund? What approaches need to take, there is hardly any precise and practical answer to these questions, and those who can answer them do not tell for free and it is also right that they should not be told for free because people do not pay attention to the advice of free.

While investing money, which methods should be adopted so that your money is safe and you also get good returns. What are the golden rules that can be used in investment? So let’s know how you should invest your money

The most important rule of money investment is that whatever money we are investing in, it should be safe. We should adopt an investment method that protects your principal and at the same time provide good returns. Therefore invest thoughtfully in a place where the money you have invested is safe.
You have to invest your money in such a way that you can get high returns. For this, financial education is most important. Without this, it will be like “shooting in the air” in the world of investment. With Financial Education, you can know the right way to invest, where to invest, how long to invest, and why. Everything will be clear to you in advance and you will be successful.
One rule of investing money is that wherever you invest your money, you do not have to do any work for returns there. Here money works itself and brings more money for you. This golden rule of investment says that you should never work for money, rather money should work for you. If you make such an investment, then nothing can stop you from becoming rich.
You need to invest your money in such a way where there are low risk and high return. There is a saying by most people “lower the risk, the lower the return, and the higher the risk, the higher the return”. While it is not so, if you invest your money by doing research, then you can get high returns easily even at low risk.
While investing money, keep in mind that do not invest all your money in one place, rather invest a little money in many places so that the risk of losing money can be greatly reduced. Diversification of money is very important while investing. Without Diversification, your money either goes to high risk or returns are very less.
While doing money investment, it is very good that you are doing Diversification of your money but only Diversify money will not work. You have to check from time to time whether good returns are coming from wherever you have invested. If you are not getting good returns from somewhere, then remove money from there and invest in the place where good returns are being received.
Money Investment is like a tap from which water (returns) comes to you continuously without doing any work. Keeping this in mind, you should understand the difference between Assets and Liability. You buy those things or invest in these things, with which the price will increase with time or it will continue to give very good returns every month or year.
Now another golden rule of investing money is that you invest your money in a place where you can get very good returns and also open many ways to invest.
Everyone has many dreams and thinks that he can use many Luxuries but most people are not able to do so. But those who know how to make good investments can also enjoy luxuries. How? Let’s know
For this, you do some of your investments so that you can buy and enjoy luxury from the returns that you get. Keep in mind you have to take Luxuries not from your own money, but from the money earned.
One thing you need to keep in mind is that you can only the person who can manage your investment effectively. If you manage your investments with another person, you will either get cheated or you may not get good returns. You can take advice from any good expert, but manage your money yourself.